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KMID : 1039220200300020196
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Journal of Korean Society of Occupational and Environmental Hygiene
2020 Volume.30 No. 2 p.196 ~ p.204
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Influencing Factors of Plasma Levels of Total Peroxide and Oxidative Stress Index in Retired Miners with Chronic Obstructive Pulmonary Disease
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Lee Jong-Seong
Shin Jae-Hoon
Baek Jin-Ee
Jeong Ji-Yeong
Choi Byung-Soon
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Abstract
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Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Increasing oxidative stress associated with COPD. The aim of this study was to evaluate the influencing factors of biomarkers for oxidative stress in retired miners with COPD.
Methods: The levels of total peroxide(TPx), total antioxidant capacity(TAC), and oxidative stress index(TPx/TAC ratio, OSI) in plasma as biomarkers for oxidative stress, serum Creactive protein(CRP) as a biomarker for inflammation, and general characteristics were measured in 93 male subjects with COPD. COPD was defined as post bronchodilator FEV1/FVC<0.7 by spirometry.
Results: Mean levels of TPx(p=0.013), TAC(p=0.010), OSI(p=0.040), and CRP(p=0.024) were higher in current smokers. Levels of TPx(β=0.445, p<0.001), TAC(β=0.490, p<0.001), and OSI(β=0.351, p<0.001) were related to CRP levels, and CRP levels were related to %FEV1 predicted(β=-0.295, p=0.003) and current smoking(β=0.214, p=0.032).
Conclusions: These results suggest that oxidative stress was related to inflammation, and inflammation were related to decreasing %FEV1 predicted and current smoking in retired miners with COPD.
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KEYWORD
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Chronic obstructive pulmonary disease, C-reactive protein, oxidative stress index, retired miner, total peroxide
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